Exosomes in hair loss. How to choose the right one?

How to Choose the Right Exosome Product and Ensure Results? What is the Role of Exosomes in Medicine?

Exosomes are tiny vesicles that act as messengers between cells. They carry proteins and lipids, influencing processes in the body by stimulating cell activity and growth. While studied for over 50 years, exosomes have recently gained attention in medicine, including aesthetics. Researchers believe they could help treat conditions like neurodegenerative diseases, tissue damage, and even cancer.

Not all exosomes work the same way—it depends on their source. For example, exosomes from bacteria can cause inflammation, while those from mesenchymal  (Mesenchymal cells are multipotent cells, meaning they can develop into different types of cells. These include bone, cartilage, fat, and muscle cells), stem cells have anti-inflammatory effects. 

 

What to Look for in Exosome Products? Facts, Not Marketing!

To avoid scams and ensure safety, check the ingredients (INCI) listed by the manufacturer—not just the marketing materials. Key points:

1. Extracellular Vesicles (EV): This is the scientific name for exosomes. Products claiming to contain exosomes must list this ingredient and meet strict standards (ISEV, MISEV).
2. Conditioned Media: These are cell culture byproducts, often containing less than 0.1% exosomes and lots of impurities.
3. Other Active Ingredients: Products like collagen or PRP (plasma) are not exosomes and work differently. True exosomes can penetrate the skin and stimulate cellular pathways, unlike larger molecules.
4. Plant Extracts: Antioxidants from fruit or plant extracts are not the same as extracellular vesicles. They lack the mRNA sequences needed to trigger specific cellular processes.

 

 

FDA Warning About Exosomes (2019)

The FDA has cautioned against unregulated exosome products, as many were found to be contaminated or fake. Only products with proper standardization and certification are safe. 

source: https://www.fda.gov/vaccines-blood-biologics/safety-availability-biologics/public-safety-notification-exosome-products

 

How to Identify Safe and Effective Exosome Products?

Before buying, ask these questions:

1. What patents, research, and standards back the product?
2. Is production standardized under GMP, ISEV, and MISEV guidelines?
3. What purification technology is used to ensure safety and effectiveness?

The only fully approved exosomes technology in Europe are ASCEplus, derived from Rosa Damascena and manufactured under strict quality controls by INNMEDIS and ExoCoBio. Always verify with a hologram or lot number to ensure authenticity. By focusing on trusted products, you can ensure both safety and results in your practice.

Why Not Blood-Derived Exosomes?

Blood-derived exosomes are gaining attention in the aesthetic medicine market. Despite their potential benefits, there are many myths and controversies surrounding their use. Here's a breakdown of the facts about their safety, isolation procedures, and the complexity of obtaining fully purified exosomes from blood.

 

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Safety Concerns

1. Limited Research: Most studies on autologous (self-derived) exosomes have been conducted in laboratories (in vitro). Only a few small studies on humans (in vivo) have been done, with participant groups of just 2-4 people, who underwent very strict health screenings.

2. Potential Risks: If the donor (the person providing the blood) is unwell, their exosomes might carry abnormal miRNA codes. When these exosomes are concentrated and used, they could worsen the recipient's health.

3. Screening Challenges: Without thorough testing of the donor's health, using autologous exosomes is controversial due to safety concerns.

4. Purity Issues: So far, no one worldwide has successfully isolated completely purified exosomes from whole blood or plasma. This makes the process unreliable for safe use in treatments.

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Insights from Experts

Professor Jan Lötvall, a leading scientist in the field and the discoverer of exosomes, emphasized these concerns in his interviews during international conferences. He explained that while blood-derived exosomes are promising, their safety and purity remain significant challenges.

For now, blood as a source of exosomes requires much more research to ensure safe and effective use in medicine.

 

What Types of Hair Loss Benefit Most from Exosome Treatments?

ASCEplus HRLV exosomes offer a versatile and reliable solution for individuals dealing with various types of hair loss. Whether it's localized concerns like bald spots or more widespread thinning, these exosomes provide targeted and effective care. Their unique adaptability allows them to address diverse patterns and severities of hair loss, making them suitable for a broad range of needs.

Designed to enhance hair strength and density, they cater to anyone seeking to revitalize their hair and improve its overall health. This flexibility makes ASCEplus HRLV exosomes an exceptional choice for personalized hair restoration and strengthening treatments.

What Potential Side Effects Could Arise from Exosome Treatment?

Exosome therapy is widely regarded as safe and well-tolerated, with no major side effects associated with the treatment. However, as with any medical procedure, there are potential minor risks to consider. Most side effects are localized and temporary, resolving quickly, often concealed by new hair growth.

You might experience mild redness (erythema) that typically lasts 1-3 days but could extend up to a week. Swelling (oedema) may occur, lasting up to a week, and small scabs might form for a few days—be sure to avoid scratching them and apply moisturizer if they feel itchy. Some minor bruising could also appear, lasting up to a week.

In rare cases, sensitivity to the treatment components might cause an allergic reaction. While uncommon, improper sterilization protocols could lead to infection, and inadequately purified exosomes might trigger unintended immune responses or inflammation. These risks are highly unlikely when the procedure is performed by qualified professionals using high-quality exosome products.

How Many Treatments Should You Have?

The ASCE+ HRLV hair growth product starts showing results as early as 5 days after the treatment. New hair growth typically appears within 2 months. For the best results, it’s recommended to have at least 5 treatments.

When Will I See Results from Benev Exosome Treatments?

Results from Benev Exosome treatments can vary from person to person, depending on factors like skin or scalp condition. Some people notice improvements in skin texture or hair health soon after treatment, with results continuing to get better over time.

The speed and level of improvement depend on things like your age, the severity of the issue, and how your body responds to the treatment.

Most people see gradual changes as the exosomes help repair and regenerate cells. Regular treatments can lead to even better and longer-lasting results.

 

source: http://www.asceplus.com/technology

Please note: The information provided here is for informational purposes only and does not constitute medical advice. If you have any serious health issues, are taking medications, or have concerns about your health, please consult your GP or a medical advisor.