Biotin. The Essential Vitamin for Hair and Nails.

Biotin, commonly referred to as Vitamin B7, has garnered significant attention in connection to hair loss and the overall condition of hair and nails.

Biotin plays a role in the production of keratin, a protein that makes up hair, skin, and nails. It's thought that a biotin deficiency could lead to hair loss or other hair-related issues. However, significant biotin deficiencies are relatively rare because the body needs only small amounts of biotin, and it is present in a variety of foods.

If someone has a biotin deficiency, supplementing with biotin might improve hair health. However, for individuals with a balanced diet, there is no evidence to suggest that taking extra biotin will necessarily lead to better hair growth or quality. NO EVIDENCE supports improved hair or nail health with biotin supplementation (when no deficiencies exist). Thicker new hair may be observed, but scientific proof is lacking. NO EVIDENCE of adverse effects from biotin overdose.

This association has sparked numerous discussions, but what does science truly reveal about the role of Biotin in addressing these concerns?   

When considering biotin supplementation

If you consider biotin supplementation whether for addressing a deficiency or enhancing existing hair health, it's crucial to understand a few key facts. Biotin indeed plays a role in promoting the growth of new hair, skin, and nails. However, it's essential to note that the mechanism is not known and it won't have a significant impact on the health of already existing, long hair – those are essentially the 'dead' parts of our strands.

To nurture and improve the quality of long hair, relying solely on biotin might not be sufficient. Incorporating proper hair care practices, such as using suitable conditioners, masks, serums, and undergoing regeneration treatments, becomes paramount. These treatments focus on maintaining the health and vitality of the existing hair.

Moreover, it's vital to recognize that our bodies require a combination of micronutrients, macronutrients, amino acids, water, and fatty acids to build new and healthy hair. Simply taking biotin supplements won't be as effective if the body lacks the necessary materials for the growth of strong, vibrant hair. Therefore, it's essential to complement biotin intake with a nutrient-rich diet to provide the building blocks needed for optimal hair growth.

In essence, while biotin can be a beneficial component in promoting hair health, it works best when combined with a holistic approach that includes proper hair care practices and a balanced, nutrient-rich diet."

Few essential facts about biotin

How Much Biotin is Absorbed:

• The efficiency of this process depends on how much biotin is around. At low concentrations (less than 5 µmol/L), there's a special transportation system that takes over.
• However, when there's a lot of biotin around (more than 25 µmol/L), it can just pass through the cell membrane without needing special assistance.
• Biotin is a weather soluble vitamin and hydrating your body is crucial for biotin absorption and for your hair. 

Regulation and Control:

• The amount of biotin that gets absorbed depends on how much is in your diet.
• The process is controlled by different factors, like protein kinase C (a type of protein), calcium (Ca2+), calmodulin (a protein), and certain genes (KLF-4 and AP-2).
• There's a clever mechanism where the gene responsible for biotin absorption is regulated by biotin itself - it's like the body adjusting its own biotin intake.

How Much is Too Much:

• If you take a lot of biotin (600 times more than the usual amount in your diet), your body will absorb 100% of it. Which is way too much, you don't need as much, as our body is able to cumulate Biotin and use it as needed.

In simple terms, biotin absorption in the intestines is like a well-orchestrated dance. It uses different doors to get in and is influenced by the amount of biotin in your diet and controlled by various factors to make sure your body gets what it needs.

How much biotin do we need? 

• Because there's not enough info on biotin deficiency in the general population, the AI (Adequate Intake) is set based on the assumption that the average diet meets the needs.
• The resulting AI for adults is set at 30 μg/day, considering available evidence. 

Where can you find biotin?

You can obtain biotin from a variety of foods, including

• Meat, fish, eggs, and organ meats (like liver)
• Seeds and nuts
• Certain vegetables (such as sweet potatoes, spinach, and broccoli)

Who suffers because of biotin deficiency ? 

While most people obtain enough biotin from their diet, certain groups are more prone to biotin deficiency:

• Individuals with a rare genetic disorder known as "biotinidase deficiency"
• People with alcohol dependence
• Pregnant and breastfeeding women
• Individuals taking medications that can lead to B7 deficiency

Biotin drug interactions 

If you're on anticonvulsant medications, they might affect how your body takes in and uses biotin. Similarly, lipoic acid, if taken in large amounts, can compete with biotin for entry into cells, potentially impacting the function of important enzymes in the liver. Always consult with your healthcare provider about any concerns or potential interactions with medications or supplements.

Signs of Biotin Deficiency:

• Biotin deficiency can happen in different situations, like in people with specific genetic conditions, severely malnourished children, or those consuming a lot of raw egg whites (which contains a protein called avidin that binds to biotin, preventing its absorption).
• Clinical signs of biotin deficiency include skin issues (periorificial dermatitis), eye inflammation (conjunctivitis), hair loss (alopecia), coordination problems (ataxia), muscle weakness (hypotonia), and in severe cases, seizures and developmental delays in infants and children.

Biotin and Inaccuracy in Blood Research

Researchers, including conducted studies to explore how taking high doses of biotin supplements can affect blood tests. In one study, 6 healthy adults were given a high dose of oral biotin (10 mg/day) for a week. This dose, while much higher than the recommended daily intake, is common in over-the-counter supplements and prescribed in certain medical conditions.

The researchers then tested 9 hormones and 2 nonhormones in the participants' blood two hours after the last biotin dose and again a week later when they were not taking biotin. These tests included measurements like thyroid hormones, parathyroid hormone, and vitamin D levels.

Key findings showed that about 40% of individuals taking biotin supplements at this high dose may get inaccurate results in various hormone and biochemical tests commonly used in labs.

In a similar study,  also looked into biotin interference in immunoassays, uncovering misleading results for hormones like prolactin and thyroid-stimulating hormone. These findings highlight the importance of considering biotin interference in interpreting test results, especially when high doses of biotin supplements are involved.

In conclusion biotin has been shown to affect laboratory tests, including:

• 25-hydroxyvitamin D [25(OH)D]
• Thyroid hormones (even with a single 10mg/24h dose)
• Troponin test (used to diagnose heart attacks)
• N-terminal pro-B-type natriuretic peptide (may obscure heart issues)

 

Is Biotin Worth Considering?

• Prioritize diagnostic tests before deciding.
• For hair loss concerns, consult a QUALIFIED trichologist for accurate identification of causes and appropriate treatment.

Biotin is often associated with hair health, and some people take biotin supplements believing that it can improve the condition of their hair. However, it's essential to note that the relationship between biotin and hair health is not fully straightforward, and the scientific evidence supporting its efficacy for hair growth is limited.

 It's crucial to approach supplements with caution and consult with a healthcare professional before taking them, as excessive intake of biotin or other supplements can have potential side effects. Additionally, hair health is influenced by various factors, including genetics, overall nutrition, and other lifestyle factors. Therefore, maintaining a balanced diet and a healthy lifestyle are generally recommended for promoting overall well-being, including the health of your hair.

Crucial Reminder!

1. If using biotin or biotin-containing hair products, discontinue at least 4 days before thyroid tests.
2. Always inform your doctor about biotin use when discussing medications.

Altered results + specific treatment plans could impact thyroid function. Stay informed for optimal health.

 

Please note: The information provided here is for informational purposes only and does not constitute medical advice. If you have any serious health issues, are taking medications, or have concerns about your health, please consult your GP or a medical advisor.

 

Source:

"Biotin "Janos Zempleni,^* Subhashinee S.K. Wijeratne, and Yousef I. Hassan

"Biotin supplements and laboratory test results in neuropsychiatric practice and research" T. S. Sathyanarayana Rao, Rita Christopher,¹ and Chittaranjan Andrade²

"Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B₆, Folate, Vitamin B₁₂, Pantothenic Acid, Biotin, and Choline. Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate, Other B Vitamins, and Choline".